Vol. 9, Special Issue 1 (2024)

Author(s): Lija S and Eswari S

Abstract: Nerve injuries, irrespective of tissue involvement, disrupt the continuity of nerve fibers, leading to compromised functionality. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cell therapy across a spectrum of diseases, owing to their unique functional attributes including potent differentiation capacity, immunomodulation, and growth support. In particular, the secretome produced by Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs) plays a pivotal role in their trans-differentiation into neural stem cells, thus creating a conducive microenvironment for nerve regeneration. Through the secretion of trophic factors, WJ-MSCs provide a nurturing, protective, and activating milieu that fosters the regeneration of damaged nerves, engaging both neuronal and non-neuronal cells. This synergistic interplay holds immense potential for accelerating nerve regeneration processes and augmenting functional recovery. This review underscores the therapeutic promise of WJ-MSCs in the realm of nerve regeneration, offering insights into their mechanisms of action and future directions for clinical applications.

DOI: 10.22271/veterinary.2024.v9.i1Sk.1136