Vol. 10, Issue 8, Part F (2025)

Author(s): Parvez I Sindhi, Sneha P Modh, Shweta P Khatri, Samir H Raval, Rohit S Parmar, Ratn Deep Singh, Parth B Rathod, Jaynudin H Khorajiya and Jasmi G Patel

Abstract: The present study evaluated the ameliorative effect of Citrus medica Linn. Extract on ethylene glycol-induced urolithiasis in streptozotocin (STZ)-induced diabetic rats. Eighty male Wistar rats were divided into eight groups (I-VIII, N=10). Diabetes was induced with a single intraperitoneal injection of STZ (60 mg/kg) in groups II, IV, VI, and VIII. Urolithiasis was induced in groups III, IV, VII, and VIII using 0.75% ethylene glycol and 1% ammonium chloride. Citrus medica Linn extract (200 mg/kg/day) was administered in groups VI, VII, and VIII. STZ-treated rats showed typical diabetic symptoms, significant weight loss, hyperglycaemia, altered haematology, serum biochemistry, and 40-50% mortality. Ethylene glycol exposure led to depression, lethargy, increased urea, creatinine, and renal calcium oxalate crystal deposition. However, it failed to improve hyperglycaemia, weight loss, haematological, or biochemical changes in diabetic rats. Thus, Citrus medica Linn. Extract showed potential in mitigating nephropathy caused by urolithiasis but not in reversing STZ-induced diabetic complications.