Vol. 9, Special Issue 1 (2024)

Author(s): Manju Gari, Meemansha Sharma, Suhas KS, Haritha CV, Kishorkumar DG, Madhu CL, Anshuk Sharma, Aneesha VA, Subhashree Parida and Thakur Uttam Singh

Abstract: Present study was undertaken to assess the effect of niclosamide ethanolamine on morphometric parameters in isoprenaline (ISP)-induced cardiac injury. Cardiac injury was induced by administering the isoprenaline at a dose of 20 mg/kg body weight through subcutaneous route for 14 days. Niclosamide ethanolamine was administered @ 1 mg/kg b.w. (intraperitoneally) on alternate days for initial eight days with daily dosing of ISP in treatment group. Control group and niclosamide alone group were received vehicle and niclosamide (@1 mg/kg b.w.; I.P. alternately for initial 8 days), respectively. On day 15th (after 24 hours of last dose of isoprenaline) mice were weighed and sacrificed under anaesthesia. Heart weight and tibial length of different group mice were measured. Study reveals that absolute heart weight and relative indices viz., heart weight to tibial length were increased in isoprenaline administrated group, which have been decreased by niclosamide ethanolamine treatment. In conclusion, niclosamide ethanolamine showed improvement in heart weight and heart weight to tibial length in isoprenaline-induced cardiac injury.