Vol. 9, Special Issue 1 (2024)

Author(s): Akash Bairwa, Rebecca Metcalf and Shashikant

Abstract: Transmissible venereal tumors (TVTs) are tumors that are transmitted between male and female dogs by exchanging body cells through sexual intercourse. Cancer can spread to different parts of the body by smelling, licking, scratching or biting the affected part. This phenomenon can also be seen in wild canines. In female dogs TVT is usually located on the posterior wall of the vagina, at the junction between the vestibule, at caudal end of the penis in male dogs. Initially, the tumor is small, pink to red in color, and then grows into a large, ulcerated infection. At this time the tumor grows, and the disease becomes brittle, engorged, hemorrhagic, multi-lobular and cauliflower shaped. Serum-like vaginal discharge is observed. This study aimed to assess the occurrence of TVT in Himalayan Dogs and Effect of vincristine chemotherapy. Total 40 dogs (20 Male, 20 Female) were investigated. Diagnosis of TVT was based on Cytological Method by using Giemsa staining. Identification of cells was done using compound microscope. TVT round cells were observed in total 37 dogs (92.5%) 19 Female and 18 males. TVT positive dogs were treated with Vincristine Sulphate @ dose rate 0.025 mg/kg intravenous once weekly. 3 dogs (1 Female, 2 male) cured after first dose. 15 Dogs (8 female, 7 male) cured after 2 doses. 12 Dogs (5 Female, 7 male) cured after 3 doses. 4 Dogs (2 Female, 2 male) fully recovered using fourth dose of vincristine. 3 female dogs were treated with 5th dose but not successfully recovered.