Vol. 10, Issue 9, Part E (2025)

Author(s): Prajwal TR, PT Ramesh, Lathamani VS, Malathi V, Sharada R and Renukaradhya GJ

Abstract: The present study evaluated the diagnostic potential of urine albumin-to-creatinine ratio (UACR) in detecting renal dysfunction in dogs and its correlation with conventional biomarkers. Thirty-seven dogs were enrolled, including six healthy controls, six acute kidney injury (AKI) cases, and 25 dogs with chronic kidney disease (CKD) staged as per IRIS guidelines. Serum creatinine and blood urea nitrogen (BUN) levels were significantly elevated in AKI and CKD dogs compared to controls, indicating progressive azotaemia. UACR values were markedly increased across all CKD stages and in AKI, showing a strong correlation with conventional renal biomarkers. Notably, UACR levels rose progressively with advancing CKD stages, highlighting its utility in disease staging and monitoring. The findings demonstrate that UACR is a sensitive and non-invasive biomarker for early diagnosis and progression assessment of canine renal dysfunction, supporting its integration into clinical practice.

DOI: 10.22271/veterinary.2025.v10.i9e.2570