Vol. 10, Issue 9, Part C (2025)

The present study was undertaken to investigate the clinico-physiological, haemodynamic and haemato-biochemical effect of ketamine-guaifenesin and ketamine-midazolam as induction with isoflurane maintenance anaesthesia in 12 buffaloes divided into two equal groups. In group I, ketamine (2 mg/kg, IV) and guaifenesin (50 mg/kg, IV) while, in group II, ketamine (2 mg/kg, IV) and midazolam (0.05 mg/kg, IV) were used for induction of anaesthesia. The intubated buffaloes were connected to the large animal anaesthesia machine and isoflurane in 100% oxygen was given. Despite cardiopulmonary depression ketamine-guaifenesin and ketamine-midazolam as induction anaesthesia along with isoflurane maintenance anaesthesia provides clinico-physiological and haemodynamic stability in buffaloes.