Vol. 10, Issue 7, Part E (2025)

Background: Bisphenol A, an industrially used compound for resins and plastics, is not only an already recognized endocrine disruptor but also a lasting environmental pollutant. Its persistence for long periods of time within soil and water ecosystems results in long-lasting ecological hazards, affecting water animals and being integrated into the food chain, ultimately risking the health of humans. Among its biological activities, Bisphenol-induced nephritis is primarily mediated through inflammatory and oxidative stress pathways, including cytokines such as Tumor Necrosis Factor-alpha, Interleukin-6, and Interleukin-22. Resveratrol, being a naturally occurring polyphenol, has also been found to have intense anti-inflammatory and antioxidant abilities, suggesting protective potential for Bisphenol induced renal toxicity.
Objective: This experimental study aimed to study histopathology alteration and cytokine response when nephritis is induced through BPA and find out the protective influence of resveratrol through Tumor Necrosis Factor-alpha, Interleukin-6, and Interleukin-22 modulation.
Methods: Forty mature male Wistar rats were equally distributed into four groups (N=10): Control, Bisphenol (50 mg/kg/day), Bisphenol + Resveratrol (20 mg/kg/day), and resveratrol only. Treatments were given orally for 28 days, renal tissues were histologically analyzed using hematoxylin and eosin staining and ELISA for tissue and serum cytokines Tumor Necrosis Factor-alpha, Interleukin-6, and Interleukin-22 quantitation.
Results: BPA exposure caused significant renal injury with granule destruction, tubular necrosis, and inflammation of the interstitial spaces. Pathological evidence was concurrent with significant increases in Tumor Necrosis Factor-alpha, Interleukin-6, and decrease Interleukin-22 (p<0.05). Administration of resveratrol significantly safeguards your kidney structure, repressing the detrimental effect of the Administration of resveratrol significantly safeguards your kidney structure, repressing.
Conclusion: Bisphenol is an environmental contaminant as well as nephrotoxic ant that results in systemic toxicity because of cytokine-mediated inflammatory responses. These toxicities are avoided by resveratrol by maintaining inflammatory mediator regulation along with structural integrity of the kidney, thereby establishing its therapeutic potential for treating Bisphenol-induced nephrotoxicity as well as requiring decreased environmental exposure.