Vol. 10, Issue 6, Part F (2025)

Author(s): SS Bhosle, DP Patil, GD Ranvir, GR Gangane, PB Ghorpade, PR Suryawanshi, SV Londhe and SV Panchal

Abstract: The present study was carried out to study the antidiabetic activity of herbal combination prepared using aqueous leaves extract of Murraya koenigii and Aegle marmelos on alloxan induced diabetic rats for a period 28^th days. Fifty Wistar rats divided into five groups, each group comprising ten Wistar rats of either sex. Group I normal control was given pelleted feed and drinking water for 28^th days. The Groups II, III, IV and V were given alloxan monohydrate @ 120 mg/kg BW. Intraperitoneal for induction of diabetes and hyperglycaemic rats were used for study. In Group III animals were treated with Metformin @100 mg/kg BW, group IV treated with herbal combination @ 130 mg/kg BW and group V treated with herbal combination @ 130 mg/kg BW concurrently administration with Metformin @ 100 mg/kg BW per orally once a day for 28^th days. Significantly increased Blood Glucose Level, AST, ALT, BUN, Creatinine Phosphokinase (CPK), Total Cholesterol and Triglyceride level was observed in diabetic rats on 0 day. In treatment groups III, IV and V significantly reduced Blood Glucose Level, AST, ALT, BUN, Creatinine Phosphokinase (CPK), Total Cholesterol and Triglyceride level on 28^th day compared with diabetic control group II animals on same day was observed. Gross pathology of liver, pancreas and kidney not showed any noticeable changes in any of the experimental rats. The wide range histoarchitectural change were predominantly noticed in liver, pancreas and kidney in diabetic control group II animal. Restoration of histoarchitecture of these organs was observed after treatment.

DOI: 10.22271/veterinary.2025.v10.i6f.2364