Vol. 10, Issue 5, Part D (2025)

Author(s): Harsh J Shah, Jacky K Pariyani, Kalyani V Shinde, Bhakti A Dave and Priyal B Dakhore

Abstract: Dermatitis is a common inflammatory skin condition in dogs, caused by allergies, infections, or autoimmune responses, leading to significant discomfort and reduced quality of life (QoL). This study evaluated the effectiveness and safety of Palmitoylethanolamide (PEA) combination-PEA 300mg + Daidzein 50mg + Genistein 4mg -in 18 dogs suffering from dermatitis. Dogs received PEA Combination twice daily for 28 days and were assessed on day 0 (baseline), 07, 14, 21 and 28 (End of study). Key evaluations included Canine Atopic Dermatitis Extent and Severity Index-4 (CADESI-4) and owner-reported QoL. CADESI-4 reduced significantly from 52.27±5.51 to 3.83±2.89 (p<0.001). QoL score significantly improved from 13.33±2.11 to 0.61±0.97 (p<0.001), while family concern scores improved from 5.55±1.33 to 0.22±0.42. Two cases of vomiting were reported as adverse events. The study concluded that PEA combination significantly reduced dermatitis and improved QoL in dogs, demonstrating safety and tolerability with no major adverse event.

DOI: 10.22271/veterinary.2025.v10.i5d.2261