Vol. 10, Issue 5, Part D (2025)

Author(s): Mayur Purankar, Alka Sawarkar, Mayur Pawashe, Manoj Patil, Swati Umap and Vivek Borekar

Abstract: Breast cancer is the most frequently diagnosed cancer in females, and its metastatic state represents the second leading cause of death. The incidence of breast cancer is increasing at alarming places in India, mainly in metropolitan cities, women are likely to suffer from breast cancer during their lifetime. Also, based on incidence, breast cancer is becoming the number one in females, pushing cervical cancer to second place. Therefore, animal models of breast cancer are becoming a significant area of Interest for studying the etiology, prevention, and treatment of cancer. Mammary tumors arise spontaneously in a few animal species, for example, dogs, rats, and mice. For practical reasons, most experimental breast carcinogenesis studies are conducted with rodents. various parts of N. cadamba i.e. leaf, bark, fruit and flower, have been traditionally used by many tribes and communities in India against fever, cough, sour throat, infections and inflammation. The leaves of Neolamarckia cadamba (NC), (family: Rubiaceae) are traditionally used to treat breast cancer in Malaysia; however, this traditional claim has yet to be scientifically validated. The ethanol extract of NC leaves has an anticancer impact on MCF-7 human breast cancer cells by inducing apoptosis and cell cycle arrest, hence validating its traditional use for breast cancer treatment.