Vol. 10, Issue 5, Part B (2025)

Author(s): Harsh J Shah, Jacky K Pariyani, Kalyani V Shinde, Bhakti A Dave and Priyal B Dakhore

Abstract: Chronic pain significantly affects quality of life (QoL) and behaviour in dogs. This study evaluated the efficacy and safety of a Palmitoylethanolamide (PEA) combination (PEA 300 mg + Daidzein 50 mg + Genistein 4 mg) administered twice daily for 28 days in 12 dogs with chronic pain. Assessments were conducted on Day 0 (baseline), Day 14, and Day 28 (end of study, EOS), including physical exams, Canine Brief Pain Inventory (CBPI), and owner-reported QoL scores. Results showed marked improvement by EOS: Pain Severity Score decreased from 27.58±2.74 to 16.41 ±2.60, Pain Interference Score from 47.66±2.99 to 27.41±2.96, and total CBPI score from 75.25±5.73 to 43.83 ±5.56. QoL scores improved from 21.41±2.77 to 7.58±1.56, and Family Concern score from 10.08 ±2.15 to 3.50±1.44. Three mild adverse events (two cases of vomiting, one case of fever) were reported.

DOI: 10.22271/veterinary.2025.v10.i5b.2243