Vol. 10, Issue 11, Part D (2025)

Author(s): Ushma D Patel, SB Akhare, SV Upadhye, BK Bhadane, GA Fiske and MP Kaore

Abstract: Canine hip dysplasia (CHD) is a progressive orthopaedic disorder that predisposes dogs to osteoarthritis and degenerative joint disease. The present study evaluated the comparative efficacy of oral joint supplements alone and in combination with sodium pentosan polysulfate (NaPPS) for the conservative management of CHD. Twelve dogs (N=12) diagnosed with CHD were divided into two groups. Group I received oral glucosamine-chondroitin sulfate daily for 60 days, whereas Group II received NaPPS (3 mg/kg, subcutaneously on Days 0, 7, 14, and 21) along with the same oral supplementation. Clinical, haematological, biochemical, radiographic, and pain evaluations were performed on Days 0, 15, 30, and Both groups showed progressive improvement in mobility and reduction in pain; however, Group II exhibited earlier and significantly greater improvement (p<0.05) without any adverse effects. Haemato- logical and biochemical parameters remained within normal physiological limits, confirming the safety of both regimens. Radiographic findings indicated joint stability with non-significant structural changes over the 60-day period, possibly due to the short observation duration. The combination of NaPPS with oral supplements produced superior clinical improvement, likely due to synergistic chondroprotective, anti-inflammatory, and analgesic effects. These findings support the use of NaPPS as a safe and effective adjunct in the conservative management of canine hip dysplasia.

DOI: 10.22271/veterinary.2025.v10.i11d.2728