Vol. 10, Issue 11, Part B (2025)

Author(s): Varunprasath R, K Ravikumar, R Anil Kumar and K Loganathasamy

Therapeutic measures to control unwanted pregnancies were often limited to those beyond 30 days of gestation. However, pregnancy can be terminated as soon as implantation occurs. Hence, the present study was aimed at assessing the effect of aglepristone on early post-implantation termination. Twelve bitches were randomly allotted to two groups. Group I received aglepristone (10 mg/kg S/C, two doses 24 hours apart), and Group II served as untreated controls. Treatment efficacy and physiological responses were assessed through clinical observation, haematological analysis and Doppler ultrasonography. Pregnancy termination occurred within 5.5 ± 0.22 days, confirmed by ultrasonographic evidence of the disappearance of gestational sacs. Progesterone concentration did not decrease after the start of treatment. An increase in TLC, ALP and uterine artery RI, and PI was recorded post-treatment. Minor side effects were observed in this study, which concludes aglepristone is a safe and effective abortifacient for early post-implantation pregnancy termination in bitches.

DOI: 10.22271/veterinary.2025.v10.i11b.2705