Vol. 9, Special Issue 6, Part A (2024)

In the field of veterinary clinical practice, sulphadimidine is frequently used to treat enteritis caused by bacteria. The final assessment of any therapy depends upon the attainment of an effective drug concentration in vivo, which requires the choice of an appropriate medication dosage. Data from pharmacokinetic studies are used to determine the dosage regimen. In view of this, a pharmacokinetic study of sulphadimidine in cattle calves following i.m was undertaken to study the disposition kinetics. The concentration of sulphadimidine in plasma of cattle calves was analysed by High Performance Liquid Chromatography. A dose of 100 mg.kg-1 was used for i.m. Studies. The initial mean plasma concentration of 29.91µg.ml-1 sulphadimidine was found in plasma of male cattle calves, which declined to the minimum concentration of 0.46µg. ml-1 (72 h), in these animals. The t1/2 β, Vd (area), ClB and AUC of sulphadimidine in male cattle calves were observed to be 9.54±0.12 h, 0.56 ±0.01 L.kg-1, 40.98±0.38 mL.kg-1.h-1, 2440.31±21.99.43 µg.mL-1.h-1. On the basis of present pharmacokinetic study, the i.m. dosage regimen of 70 mg.kg-1 was calculated as priming dose and 40 mg.kg-1 as maintenance dose for cattle calves at dosing intervals of 12h.