Abstract: Six domestic cats (five females and one male) were presented to the Veterinary Clinical Complex at the College of Veterinary Science and Animal Husbandry, Kamdhenu University, Anand, displaying symptoms of intense pruritus, excoriated crusty lesions on ear margins, alopecia, and lesions surrounding the eyes, nose, forehead, ventral abdomen, and limbs. Anamnesis from the owner revealed pruritic dermatitis in family persons who have close contact. Diagnostic evaluation included skin scraping. Microscopic examination of skin scrapings under 10x and 40x magnification confirmed the presence of Notoedres cati mites, indicating notoedric mange. The treatment regimen involved a 6% selamectin spot-on solution, topical benzyl peroxide shampoo, cetirizine syrup, a mupirocin ointment, and a multivitamin & aminoacid syrup. All treated cats showed significant clinical improvement, with symptom remission. Follow-up skin scrapings on the 28th day post-treatment revealed no mites, confirming recovery and treatment efficacy. This case series highlights the importance of prompt diagnosis and effective therapeutic interventions in the management of feline notoedric mange.