Vol. 9, Issue 4, Part J (2024)

Author(s): K Vijayakaran, K Jayalakshmi, PK Ramkumar, R Lakshmi, DT Kaarthick, A Vijayarajan and M Senthil Kumaran

Abstract: A Jersey crossbred cow with a swollen udder and reduced feed intake for the past four days was presented to the Veterinary Clinical Complex, Veterinary College and Research Institute, Orathanadu. On physical examination, the animal had hyperthermia and swollen udder indicative of mastitis. Fecal examination revealed the presence of amphistome eggs. The animal was positive for both theileriosis and anaplasmosis on peripheral blood smear examination. The animal was treated for mastitis and haemoprotozoal infection with parenteral administration of antibiotics and advised the owner to give 100 mL of Oxyclozanide-Levamisole suspension for amphistomiasis. But the owner accidentally drenched 3 times the actual dose. The animal developed toxicity symptoms like salivation, diarrhea, tenesmus, tachypnea, arched back and colic pain which mimicked cholinergic symptoms. The animal was treated with Inj. Normal Saline, Inj. Atropine Sulphate, Inj. Chlorpheniramine maleate, Inj. Vitamin B complex, Inj. Pantoprazole, Inj. Flunixin meglumine. After administration of atropine, the cholinergic symptoms reduced but there were colic signs. On 2^nd day, the animal had mild salivation, tenesmus, and mucoid diarrhea with mild dyspnea. The same treatment protocol was followed along with ascorbic acid, dicyclomine, activated charcoal and egg white. On the third day, the same treatment protocol was followed, and the animal showed an uneventful recovery from the effects of oxyclozanide-levamisole toxicity.