Vol. 9, Issue 4, Part J (2024)

The current investigation involves a computer-based evaluation of Tolfenpyrad, a pyrazole insecticide, using online tools such as Swiss-ADME, Pass prediction and Molinspiration Cheminformatics. According to Swiss-ADME results, Tolfenpyrad adheres to all drug likeness criteria, demonstrating high lipophilicity but limited water solubility. It serves as an inhibitor for numerous cytochrome enzymes and falls within a favorable range for bioavailability, also exhibiting good ability to cross the blood-brain barrier and lacking p-glycoprotein substrate interactions. PASS prediction indicates its role as a CYP2H substrate and highlights its potential in COPD treatment, antiasthmatic effects, calcium channel activation, as well as significant contributions to conditions like hypercholesterolemia, respiratory failure, and neutrophilic dermatosis. According to Molinspiration analysis, Tolfenpyrad displays moderate biological activity.