Vol. 9, Issue 4, Part D (2024)

Author(s): S Simran Kour, G Srividya, P Ravikumar, K Sudhakar, P Naga Mounika and V Sri Harshini

Abstract: The study aimed to assess the hematological profile of rats treated with Sardinella longiceps extract (SLFE) and quercetin against carbon tetrachloride (CCl₄)-induced toxicity. Male Wistar rats (150-200 g) were divided into five groups. The control group received 1% DMSO orally for 3 weeks and olive oil intraperitoneally (i.p.) twice a week during the 2^nd and 3^rd weeks. Groups II to V were administered CCl₄ (1ml/kg b.wt. in olive oil, 1:1) i.p. twice weekly in the 2^nd and 3^rd weeks. Groups III and IV received SLFE (300mg/kg b.wt.) and quercetin (30mg/kg b.wt.) orally daily for 3 weeks, respectively. Group V was coadministered SLFE and quercetin daily for 3 weeks. CCl₄ exposure led to significant reductions (p < 0.01) in hemoglobin, and significant decreases (p < 0.05) in red blood cell count, hematocrit compared to the control group. Supplementation with SLFE and quercetin individually mitigated these alterations, and their combination showed superior protective effects. The study concluded that SLFE and quercetin effectively ameliorate the hematological toxicity induced by CCl₄.

DOI: 10.22271/veterinary.2024.v9.i4d.1549