Vol. 9, Special Issue 3, Part E (2024)

Author(s): Ayushi Chourasia, Palanisamy Sankar, Appusamy Jagadeeswaran and Rajamanickam Madheswaran

Abstract: The present experiment pertains to the protective role of nanoquercetin against haematological toxicity induced by fluoride during 42 days exposure. Nanoquercetin (NQC) exhibited a spherical shape with the mean particle size of 240.8 nm. Rats were randomly divided into four groups of six each. Group I was kept as the control and other three groups (II, III and IV) were exposed to sodium fluoride (100 ppm) daily through drinking water for 42 days. Groups III and IV were administered quercetin (50 mg/kg bw) and NQC (25 mg/kg bw) respectively, by oral gavage for the period of 42 days. Exposure of rats to sodium fluoride caused significant changes of some haematological parameters in treated rats compared to controls. Co-administration of quercetin and nanoquercetin with fluoride restored some of the haematological parameters to near-normal values. Therefore, our investigation revealed that nanoquercetin given better protection against fluoride-induced toxicity.