Vol. 9, Issue 3, Part I (2024)

Author(s): T Mohanapriya, M Thangapandiyan and R Sridhar

Abstract: The common vascular endothelial neoplastic conditions are haemangioma and haemangiosarcoma, specifically in the spleen, with variable clinical presentations and outcomes. This study presents a comparative analysis of three cases of canine splenic haemangioma and two cases of haemangiosarcoma, examining them in gross, cytological, and histopathological aspects. The gross morphology between the two has a wide range of differences like solitary nodule to irregular multiple red raised areas, and the histopathology of haemangioma showed blood-filled vascular channels lined by well-differentiated endothelial cells, with minimal atypia and focal haemorrhage and for haemangiosarcoma revealed irregular vascular spaces lined by plump to flattened hyperchromatic endothelial cells, coagulative necrosis, fibrin deposition, haemosiderin pigmentation, and anaplastic changes. The CD31 marker was applied to haemangiosarcoma splenic tissues and it showed strong immunoreactivity in the neoplastic endothelial cells.

DOI: 10.22271/veterinary.2024.v9.i3i.2459