CONTACT: +91-9711224068
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal

Vol. 9, Issue 3, Part C (2024)

Efficacy of guar gum (Cyamopsis tetragonolobus) on alloxan induced diabetic rats

Author(s): Rahul Thakur, SR Rajurkar, Nitin D Jadhav, GM Chigure, CS Mamde and MD Jadhav
Abstract: Sixty rats were divided into five groups comprising of twelve rats of either sex in each group. The group II, III, IV and V rats were administered alloxan @ 150 mg/Kg body weight intra-peritoneal and Group I served as a control group. No any sign any apparent behavioral changes were in the control group of rats, however, group II rats showed symptoms of dullness, depression polydipsia and polyuria.
The group III, IV and V rats treated orally with metformin @ 100 mg/kg body weight, Guar gum @ 10 gm/100 gm and combination of Guar gum @ 10 gm/100 gm of feed and metformin @ 100 mg/Kg body weight respectively. There was significant increase in the blood glucose level, serum triglyceride, serum cholesterol, serum LDL, serum AST and serum ALT level values in the treatment groups on 0th day and were significantly reduced from 14 days onward and on 28th day it was come down to normal level in the group treatment with Guar gum @ 10 gm/100 gm of feed. Grossly liver and pancreas did not showed any noticeable visual change in any of the experimental rats. No significant change in weights of liver and pancreas in treatment groups. The histopathological changes were predominantly noted in liver and pancreas suggesting induction of diabetes in group II animals. However, restoration of histoarchitecture of these organs was observed after the treatment in these groups.
Pages: 195-198  |  126 Views  12 Downloads


International Journal of Veterinary Sciences and Animal Husbandry
How to cite this article:
Rahul Thakur, SR Rajurkar, Nitin D Jadhav, GM Chigure, CS Mamde, MD Jadhav. Efficacy of guar gum (Cyamopsis tetragonolobus) on alloxan induced diabetic rats. Int J Vet Sci Anim Husbandry 2024;9(3):195-198.
Call for book chapter
International Journal of Veterinary Sciences and Animal Husbandry