Vol. 9, Issue 2, Part H (2024)

Author(s): Abdulkadir A Makwana, Dhaval T Fefar, Rajkumar S Delvadiya, Khevana A Thakore, Swati S Patel, Urvesh D Patel, Amit R Bhadaniya and Kapil G Gajera

Abstract: The significance of Aluminium oxide nanoparticles (Al₂O₃NPs) has grown due to their versatile applications across industrial and biomedical sectors. Despite their promising attributes, concerns about their potential toxicity have arisen. Hence, this study was conducted to investigate and address these concerns. Total four groups of Wistar rats (each group having 6 male and 6 female Wistar rats) were used, control group and other three treated groups (T₁, T₂ and T₃) which were orally treated with Al₂O₃NPs at following concentrations of 50 mg/kg b.wt., 100 mg/kg b.wt. and 200 mg/kg b.wt. respectively for 28 days. Exposure to Al2O3 NPs initiate the ROS formation and alter the antioxidant defence mechanism of liver which leads to increase in the activity of catalase and super oxide dismutase enzymes and elicit the level of malondialdehyde in treatment groups of animals. In haematological findings the effects of Al₂O₃NPs exposure alter the Haematocrit %, TEC and increase WBCs indicative for inflammatory response and Al2O3NPs exposure also leads to significant increase in hepatic leakage enzymes (ALT, AST), hepatic induced enzymes (ALP), total bilirubin, indirect bilirubin level in treatment groups. In histopathological examination treatment related changes were noted.

DOI: 10.22271/veterinary.2024.v9.i2h.1257