Vol. 9, Issue 1, Part N (2024)

Author(s): Sanjay Kumawat, Suman Verma, Dhirendra Kumar and Dinesh Kumar

Abstract: Nephropathy is the major consequence in long term hyperglycemia. Herbal extracts impart a range of important pharmacological action that may retard the progressive decline in renal function in diabetes. This present work was conducted to explore the ameliorative effect of ethanolic extract of S. robusta resin (SRE) in in long term hyperglycemia linked kidney failure in rats as it has phenolic components which show anti-oxidative properties. Resin was extracted with 70% ethanol using a Soxhlet assembly and concentrated under rotary evaporator. Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg). Animals were treated once daily for eight weeks as follows: normal control with aqueous vehicle (0.5% CMC), normal with SRE (300 mg/kg), Diabetic control with vehicle and Diabetic with SRE (30,100 and 300 mg/kg). Animals from each group were sacrificed and collected the granulation tissue which was used for the estimation of antioxidant enzyme activity and lipid peroxidation by spectrophotometer. SRE treated animals exhibited markedly improved activity of SOD and catalase, also reduced the MDA and NO as compared to diabetic control. So, the herbal extract has shown significant effect to prevent severity of kidney injury in diabetic rats. Findings emphasis the use of this plant as herbal medicine in diabetes and other relevant ailments.