One health concept is an integrated, collaborative efforts of multiple disciplines working locally, nationally, and globally, to attain optimal health for people, animals and environment. It is particularly important to prevent, detect, and respond to global health threats such as COVID-19 pandemic. This one health concept is particularly relevant for food and water safety, nutrition, control of Zoonosis, drug resistance, environmental contamination, vector-borne diseases and other health threats shared by people, animals, and the environment. Parasitology is an example of the holistic approach of both medical and veterinary medicine. Parasitic zoonosis via contaminated food and water, Bite of vectors, faeco-oral route or oral Penetration, through skin and mucous membranes, Blood transfusion, any organ transplant and Autoinfection. The recent development of diagnostic innovations focusing on parasites of zoonotic importance will be introduced showcasing the present and future dimensions, opportunities, and applications.