Vol. 8, Issue 5, Part C (2023)

The aim of current study was to assess potential antioxidant status Wistar of naringenin (NG) in mitigating testicular toxicity induced by 5-Fluorouracil (5-FU) in rats. The experimental rats were divided into four groups (n=6 each): Group I-(normal saline), Group II-(5-FU), Group III-(NG) at a dosage of 100 mg/kg body weight-orally and Group IV received both 5-FU+NG. On 28^th day, we observed significant reduced in testicular weights in group-II rats. In addition, results exhibited a significant (p<0.01) reduction in antioxidant enzyme activities (SOD, CAT and GSH) accompanied by an increase in lipid peroxidation (LPO). However, Group IV rats, received both 5-FU and NG displayed a substantial (p<0.01) increase in the activities of CAT, GSH and SOD of testis along with a decrease in LPO levels. The administration of NG effectively restored the compromised antioxidant status. This study underscores ameliorative effect of NG against 5-FU-induced testicular toxicity.