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Vol. 8, Issue 5, Part C (2023)

Role of Naringenin on 5-Fluorouracil induced testicular toxicity in Wistar Rats

Author(s): Sravathi Vemula, RaviKumar Yadala, AnilKumar Banothu, Nagarjuna Gandham, Mounika Kamishetti, Durga Veera Hanuman Donga and Bhaskar Debbarma
Abstract:
The aim of current study was to assess potential antioxidant status Wistar of naringenin (NG) in mitigating testicular toxicity induced by 5-Fluorouracil (5-FU) in rats. The experimental rats were divided into four groups (n=6 each): Group I-(normal saline), Group II-(5-FU), Group III-(NG) at a dosage of 100 mg/kg body weight-orally and Group IV received both 5-FU+NG. On 28th day, we observed significant reduced in testicular weights in group-II rats. In addition, results exhibited a significant (p<0.01) reduction in antioxidant enzyme activities (SOD, CAT and GSH) accompanied by an increase in lipid peroxidation (LPO). However, Group IV rats, received both 5-FU and NG displayed a substantial (p<0.01) increase in the activities of CAT, GSH and SOD of testis along with a decrease in LPO levels. The administration of NG effectively restored the compromised antioxidant status. This study underscores ameliorative effect of NG against 5-FU-induced testicular toxicity.
Pages: 162-166  |  145 Views  4 Downloads


International Journal of Veterinary Sciences and Animal Husbandry
How to cite this article:
Sravathi Vemula, RaviKumar Yadala, AnilKumar Banothu, Nagarjuna Gandham, Mounika Kamishetti, Durga Veera Hanuman Donga, Bhaskar Debbarma. Role of Naringenin on 5-Fluorouracil induced testicular toxicity in Wistar Rats. Int J Vet Sci Anim Husbandry 2023;8(5):162-166.
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International Journal of Veterinary Sciences and Animal Husbandry