Abstract: The current study was conducted to investigate hematobiochemical alterations in hypertensive dogs. Out of a total of 6856 adult (>6 years) dogs, 87 dogs were diagnosed to have hypertension (>150 mm Hg) when measured with Vet Doppler BP machine. Blood samples were obtained from the dogs in the study group to evaluate different hematobiochemical parameters. Haemogram (HB: 9.48±0.67g/dl, PCV: 30.22±2.09%, TEC: 4.56±0.31 million/cumm) of the hypertensive dogs was significantly (p < 0.01) reduced when compared to apparently healthy dogs. There was a significant (p <0.01) increase in mean TLC with significant (p <0.05) neutrophilia in hypertensive dogs as compared to apparently healthy dogs whereas, the eosinophils, lymphocytes, and monocytes showed no significant changes. Biochemical parameters (BUN: 63.13 ± 12.99 mg/dl, Creatinine: 5.54 ±1.14 mg/dl, SDMA: 20.70±3.91 µg/dl, ALP: 223.47±36.77 IU/L, ALT: 77.12±18.94 IU/L, Glucose: 112.50±20.26 mg/dl, Triglycerides: 71.55 ± 4.22 mg/dl, Cholesterol: 203.82 ± 12.22 mg/dl) of the hypertensive dogs were significantly (p < 0.01) elevated when compared to apparently healthy dogs. Whereas, there was a significant (p <0.05) decrease in the serum values of total protein, albumin, and globulin (5.18±0.26 g/dl, 2.21±0.15 g/dl, 3.02±0.14 g/dl) in hypertensive dogs.