Vol. 8, Issue 4, Part E (2023)

The aim of current experimental study was to evaluate migitated effect of NG against 5-FLurouracil-induced toxicity on organ weights at different intervals. For this investigation, male rats (N=48, Albino Wistar) were employed, divided randomly into four (N=12) groups. Groups 1 and 3 each contained a control (normal saline) and ameliorative agent NG @ 100 mg/kg b.wt/day given orally for 28 days respectively, group-2-5-FU @ 20 mg/kg b.wt was injected intraperitoneal (IP) for first 5 days, group 4 injected 5-FU + NG P/O for 28 days and rats were sacrificed on 14^th and 28^th day of experiment. Body weights were individually on the 0^th, 7^th, 14^th and 2^8th day. Soon after, necropsy, gross lesions were recorded along with organ weights. A significantly reduced in body and organ weights were recorded, whereas, NG group increases body and organ weights reduced by 5-FU induced toxicity along with restored organ damage due to the anti-oxidant effect.