Vol. 8, Issue 4, Part E (2023)

This study aims to determine the MODS in dogs clinically affected with babesiosis and its best therapeutic module. Clinical examination of affected cases were carried out to evaluate body weight, rectal temperature (˚F), respiratory rate (per min), pulse rate (per min), on 0 day, 7^th day, and 14^th days. Hematological analysis was performed comprising Hb %, TEC and TLC. Biochemical examination were done to estimate Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Serum creatinine, Total Plasma Protein (TPP), Albumin, Blood Urea Nitrogen (BUN). A total of eighteen positive cases of canine babesiosis were selected for therapeutic management with different drugs as well as supportive therapy. Dogs naturally infected with babesiosis were grouped irrespective of species in the control group and three treatment groups (i.e., Group -1, 2, 3). Group 1 dogs in this group were treated with Imidocarb dipropionate @ 6.6 mg/kg s/c repeat in 2 weeks on the first day after diagnosis and sample collection. Group 2 dogs were treated with Clindamycin @ 30 mg/kg orally O.D for 10days and Diaminazine aceturate @ 3.5 mg/kg b.wt. I/M repeat after 24 hours on the first day after diagnosis and sample collection. Group 3 dogs were treated with Clindamycin @30 mg/b.wt. Azithromycin @ 10 mg/kg b. wt. Orally OD for 10 days. Besides the above noted drugs in corresponding group all the dogs received the supportive therapy consisted of DNS @ 10-20 ml/kg b.wt. RL @ 10-20 ml/kg b.wt. N-acetylcysteine @ 70 mg/kg b.wt, Frusemide @ 2 mg/kg b.wt and Metron @ 20 mg/kg. b.wt. Based on various physiological; hematological and biochemical parameters all the three treatment groups were compared for the efficacy of drugs which is more successful for the treatment of B. gibsoni were found to be 50% and 66.6% in group^{pulse rate (per min), on 0} and group-2 respectively. In group-3, the recovery percent is maximum i.e. 83%.In conclusion, it can be said that Azithral and Clindamycin is the best module of treatment against B. gibsoni infected dogs.