Vol. 8, Issue 4, Part D (2023)

Pyometra is a potentially life-threatening disease of middle to older aged intact female animals due to various risk factors especially hormonal and microbial factors. Accumulation of the pus in the uterus after a period of progesterone dominance is usually observed in this disease condition. It is well established that the Cystic Endometrial Hyperplasia (CEH), a subclinical endocrine disease, usually precedes pyometra. But pyometra can develop independently of CEH. In this review, the role of various pathological and microbiological factors involved in the development and progress of pyometra will be discussed along with latest diagnostic methods for early recognition, diagnosis and therapeutic intervention.