Abstract: The anti-nutritional factor, mimosine which is mainly nephrotoxic and hepatotoxic present in the toxic plant Mimosa invisa causes severe toxic effects in cattle. In the present case study, a 5-year-old cow with the history of perineal oedema, diarrhoea, anorexia, incoordination and restlessness was attended to farmer’s door step at Ashtamichira, Thrissur, Kerala. History, phytomorphology of the toxic plant and clinical examination revealed the condition as Mimosa invisa poisoning. Therapeutically managed the mimosa poisoning with anti inflammatory drugs, loop diuretic, osmotic diuretic and liver protectant and the cow recovered completely.