Vol. 8, Issue 2, Part A (2023)

Antibodies or immunoglobulins (Ig) are important molecules found in serum that can respond specifically to antigens that stimulate their production. Immunoglobulin M (IgM) is the first antibody formed in the immune response. The present study was carried out in Bali cattle to assess the antibody response to the Haemorrhagic Septicaemia vaccine. Thirty Bali cattle were vaccinated with the Haemorrhagic Septicaemia vaccine. Serum was collected at 0 and 7-day post-vaccination. Immunoglobulin M titers before and after vaccination were estimated by IgM ELISA Kit and carried out at the BBVet, Denpasar. The result showed that the response of animals before vaccination was statistically different from the response of animals after vaccination. Regarding the changes observed in IgM for 7 days post-vaccination, research results show that vaccine administration can induce IgM titers concentration in serum significantly increased. In conclusion, the Bali cattle vaccinated with the HS vaccine could increase IgM titers concentration after 7 days.