Vol. 8, Issue 1, Part B (2023)

Author(s): Bosha JA, Asuzu IU and Amine AA

Abstract: Prosopis africana (Guill and Perr) Taub fruit methanolic extract was tested for its antinociceptive properties. 4.2% w/w dry extract yield was obtained after 48 hours of 80% methanol at room temperature during cold maceration. and occasional shake every two hours. It had a golden brown color, was sticky and odorous, and foamed as it dissolved in distilled water. In mice, the extract did not exhibit any acute hazardous effects in the studied dosage range (250-2000 mg/kg, i.p.). The maximum dose of 2000 mg/kg administered intravenously was well tolerated with just brief indications of drowsiness that persisted for three hours. With a potency equivalent to that of 2% lignocaine hydrochloride, desensitization of the guinea pig skin was demonstrated after intradermal injecting the extract at a 3 mg/ml concentration. The extract and lignocaine hydrochloride had computed slopes of 34.9 and 10.6, respectively. In contrast to previous dosages of the extract (500 and 1000 mg/kg), administration of the extract intraperitoneally (100 mg/kg) 30 minutes before sodium pentobarbitone (35 mg/kg i.p) significantly (p 0.05) decreased the sleeping period in mice. The writhings/contortions caused by acetic acid were considerably (p 0.05) and dose-dependently decreased by the intraperitoneal injection 30 minutes before the 0.7% acetic acid (10 ml/kg) was administered, doses of the extract (250, 500, and 1000 mg/kg) were administered. The extract's inhibitory impact (500 and 1000 mg/kg, i.p.) was equivalent to indomethacin's (10 mg/kg, i.p.) inhibitory effect. The findings of this research have validated the traditional usage of Prosopis africana for the relief of headaches, toothaches, and body aches.

DOI: 10.22271/veterinary.2023.v8.i1b.475