Vol. 5, Issue 4, Part C (2020)

Author(s): Anak Agung Ayu Mirah Adi, I Nyoman Mantik Astawa, I Gusti Agung Arta Putra, I Made Kardena and I Nyoman Suarsana

Abstract: A study was carried out at Faculty of Veterinary Medicine Udayana University from March 2018 to March 2020 to evaluate the possible use of anti-NDV hyperimmune sera (HIS) for immunotherapy in chickens infected with field ND virus. Hyperimmune sera (HIS) against NDV were used in this study with subcutaneous (SC) of HIS administrations. Four groups (I-IV) each consisted of 5 chickens were infected with NDV isolate. All chickens in groups I through III were treated with HIS at a dose of 1 mL per chicken whereas chickens of group IV were HIS-untreated. Chickens in group I was treated twice at 6 and 15 hours post infection (pi). Chickens of groups II were treated once at 48 h pi, whereas those in group III were treated twice at 48 h and 63 h pi. HIS treatments in ND chickens were able to prevent death and clinical symptoms especially when the treatment were given at 6 h and 15 h pi before the onset of clinical symptoms.