Progress in development of vaccine against babesiosis
Author(s): I Maqbool, RA Shahardar, ZA Ganaie, KH Bulbul, IM Allaie and ZA Wani
Abstract: In worldwide, babesiosis is one of the most important tick-borne disease caused by Babesia spp. occur in livestock which causes economic losses to the farming community by reducing the milk and meat production. Hence, mostly the field veterinarians administer some anti-babesial drugs resulting in presence of chemical residues in meat and milk which have detrimental effect in public health concern. Sometimes applications of both anti-babesial drugs as well as acaricidal drugs with indiscriminate dose rate develop of resistance against the causative organisms and vectors. Therefore, particularly in countries where large numbers of animals are at risk, important research is directed towards improved vaccination strategies. However, solid immunity develops after infection and this feature has been exploited with the use of live attenuated organisms as immunogens. Although existing live vaccines give protection, they have considerable disadvantages. Some killed vaccines have also been used on a limited basis and consist of antigens extracted from cultured material or blood of infected calves, and given with adjuvant. The degree and duration of immunity against heterologous challenge is not well documented. Irradiation has been used as a vaccine too with some successful results. The developments of novel non-live and/or live vaccines using parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection are discussed in the present communication.
How to cite this article:
I Maqbool, RA Shahardar, ZA Ganaie, KH Bulbul, IM Allaie, ZA Wani. Progress in development of vaccine against babesiosis. Int J Vet Sci Anim Husbandry 2018;3(5):107-112.