Vol. 5, Issue 3, Part A (2020)

Author(s): Paudel A and Kaphle K

Abstract: The aim of the study is to evaluate various pattern of Antimicrobial resistance of Eschirichia coli. The rational use of different generation and different groups of antimicrobials in poultry led the E.coli to be potentiated itself to a significant degree of resistance. The strain of concern was Avian Pathogenic E.coli (APEC) capable of establishing itself outside the intestine on immunocompromised bird. Avian colibacillosis is a complex syndrome characterized by multiple organ lesions with airsacculitis and associated pericarditis, perihepatitis and peritonitis. Initial viral infections, environmental factors as well as constitution of poultry may influence appearance of avian colibacillosis. However, on terms of virulence a single APEC can have different variations and there is still to learn more about. Virulence factors of APEC known are adhesins (F1- and P-fimbriae), iron acquisition systems (siderophores), hemolysins, resistance to the bactericidal effects of serum and phagocytosis. On the basis of genetic criteria, E. coli isolates are considered pathogenic containing at least five virulence APEC genes namely iss, iucd, hlyf, ompt, iron and iuta. These virulent APEC is causing significant loss in poultry industry. Also there is chance of cross resistance of these virulent APEC with human enteric E. coli if unjudicious use of antimicrobial will go on.